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Indapamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Indapamide图片
CAS NO:26807-65-8
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
吲达帕胺是一种口服活性磺胺类利尿剂,可通过降低血管反应性和外周血管阻力来降低血压。
Cas No.26807-65-8
别名吲达帕胺
化学名4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide
Canonical SMILESCC1CC2=CC=CC=C2N1NC(=O)C3=CC(=C(C=C3)Cl)S(=O)(=O)N
分子式C16H16ClN3O3S
分子量365.83
溶解度≥ 12.95mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.Target: Potassium ChannelIndapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated cardiac failure. The US trade name for indapamide is Lozol. It is described as a thiazide-like diuretic. From WikipediaIndapamide evidently induces redistribution of the cardiac output, with enhanced muscle blood flow and reduced renal perfussion, and that AVP does not seem to be involved in blood pressure regulation in mild to moderate essential hypertension under basal conditions [1]. Indapamide SR provides an effective option for initial antihypertensive monotherapy and a basis for multidrug antihypertensive strategies[2] .

References:
[1]. Pedersen, E.B., H. Danielsen, and E.S. Spencer, Effect of indapamide on renal plasma flow, glomerular filtration rate and arginine vasopressin in plasma in essential hypertension. Eur J Clin Pharmacol, 1984. 26(5): p. 543-7.
[2]. Robinson, D.M. and K. Wellington, Indapamide sustained release: a review of its use in the treatment of hypertension. Drugs, 2006. 66(2): p. 257-71.