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Trichlormethiazide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Trichlormethiazide图片
CAS NO:133-67-5
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
Trichlormethiazide 是一种口服活性噻嗪类利尿剂,具有降压作用。
Cas No.133-67-5
别名三氯噻嗪
化学名6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide
Canonical SMILESC1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)NC(N2)C(Cl)Cl
分子式C8H8Cl3N3O4S2
分子量380.66
溶解度≥ 10.75mg/mL in DMSO
储存条件Store at -20°C,protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Trichlormethiazide is a thiazide diuretic with properties similar to those of hydrochlorothiazide.Target: OthersTrichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension. In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising. Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic [1-3].

References:
[1]. Fuchs, M., B.E. Newman, and R.H. Seller, The clinical pharmacology of trichlormethiazide (Naqua). Curr Ther Res Clin Exp, 1961. 3: p. 116-24.
[2]. Reisman, E.E., Jr., Clinical experience with trichlormethiazide in edema. Angiology, 1963. 14: p. 59-63.
[3]. West, R.O., A clinical and statistical study of the effect of trichlormethiazide on blood pressure. Med Ann Dist Columbia, 1962. 31: p. 574-7.