Sandramycin ia a cyclic depsipeptideantibioticisolated from cultured broth of aNocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is anADC cytotoxin. Sandramycin is active againstGram-positive bacteriaand has potent antitumor activity^[1][2][3].

Sandramycin has antimicrobial activity wtih MIC values of 0.024 μg/mL, 0.012 μg/mL, 0.012 μg/mL, 0.098 μg/mL, 0.024 μg/mL, 12.5 μg/mL and 12.5 μg/mL forBacillus subtilis(Rec⁺) A22508-2,B. subtilis(Rec^-) A22509-2-2,Staphylocccus aureus209P-A9497,S. aureus(echinomycin-resistant) A9628,Streptococcus faecalisA96 1 1,Escherichia coliA151 19 andE. coli(actinomycin-sensitive) A21780 (AS-19), respectively^[1].
Sandramycin inhibits cancer cells growth of L1210, B16, HCT118, RPMI8226, A431, RKO, SU-DHL6 and SU-DHL10 cells with IC₅₀values of 0.02 nM, 0.07 nM, 0.8 nM, 3.8 nM, 3.1 nM, 1.3 nM, 5.9 nM and 3.3 nM, respectively^[2].

Sandramycin (0.0125-1.6 mg/kg; intraperitoneal injection; daily; for 5 days; CDF1 female mice) treatment shows moderately active in vivo against leukemia P388 in mice^[1].

1221.32

C₆₀H₇₆N₁₂O₁₆

100940-65-6

山卓霉素

• Antibiotics
• Other Antibiotics

Nocardioides sp.

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.