Propargyl-PEG3-acid

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Propargyl-PEG3-acid

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1347760-82-0

包装与价格：

包装	价格(元)
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

Propargyl-PEG3-acid是一种不可降解 (non-cleavable) 的含 3 个单元 PEG 的 ADC linker，同时也是基于PEG的PROTAC linker,可用于合成6-OHDA-PEG3-yne。6-OHDA-PEG3-yne 包含6-OHDA (HY-B1081, HY-B1081A) 和Propargyl-PEG3-acid。

生物活性

Propargyl-PEG3-acid is anon-cleavable(3 unit PEG)ADC linkerand also a PEG-basedPROTAClinker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA (HY-B1081, HY-B1081A) and Propargyl-PEG3-acid^[1].

IC₅₀& Target

PEGs	Non-cleavable

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

分子量

216.23

性状

Liquid

Formula

C₁₀H₁₆O₅

CAS 号

1347760-82-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month