Azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis ofantibody-drug conjugates (ADCs). Azetidine-3-carboxylic acid is also a alkyl chain-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1][2

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

101.10

Solid

C₄H₇NO₂

36476-78-5

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