m-PEG10-acid is anon-cleavable10 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1]. m-PEG10-acid is also a PEG-basedPROTAClinkerthat can be used in the synthesis ofPROTACs^[2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

500.58

C₂₂H₄₄O₁₂

2409969-94-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.