m-PEG8-Ms is a PEG-basedPROTAClinkercan be used in the synthesis ofPROTACs. m-PEG8-Ms is acleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

462.55

C₁₈H₃₈O₁₁S

1059588-19-0

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