Propargyl-PEG8-acid is a PEG-basedPROTAClinkercan be used in the synthesis ofPROTACs. Propargyl-PEG8-acid is acleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs). The ADCs can be used inbacterialinfections caused by Gram-negative bacteria^[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

436.49

Liquid

C₂₀H₃₆O₁₀

2055014-94-1

Room temperature in continental US; may vary elsewhere.

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)