Description: AkaLumine HCl, an open-ring analog of CycLuc1, is a novel luciferin analog and substrate for firefly luciferase. The bioluminescence produced by AkaLumine in reactions with native firefly luciferase is in the near-infrared wavelength ranges (λmax=677 nm), and yields significantly increased target-detection sensitivity from deep tissues with maximal signals attained at very low concentrations, as compared with D-luciferin and emerging synthetic luciferin CycLuc1.
References: Nat Commun. 2016 Jun 14;7:11856.
Related CAS: 1176235-08-7 (free acid)