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2,3-DCPE hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2,3-DCPE hydrochloride图片
CAS NO:418788-90-6
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍

2,3-DCPE is a proapoptotic compound with selectivity for cancer cellsversusnormal human cells

Cas No.418788-90-6
化学名2-((3-(2,3-dichlorophenoxy)propyl)amino)ethanol hydrochloride
Canonical SMILESClC1=CC=CC(OCCCNCCO)=C1Cl.Cl
分子式C11H15Cl2NO2.HCl
分子量300.61
溶解度20 mg/ml in DMSO
储存条件Desiccate at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2,3-DCPE is a proapoptotic compound with selectivity for cancer cells versus normal human cells. It induces apoptosis in vitro in various cancer cell lines (IC50s = 0.89-2.69 μM) more effectively than in normal human fibroblasts (IC50 = 12.6 μM). 2,3-DCPE down-regulates Bcl-xL, however forced overexpression of Bcl-xL is sufficient to block 2,3-DCPE apoptosis induction.[1] 2,3-DCPE can induce S-phase arrest, upregulate p21, and activate ERK.[2]

Reference:
[1]. Wu, S., Zhu, H., Gu, J., et al. Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol Cancer Research 64, 1110-1113 (2004).
[2]. Zhu, H., Zhang, L., Wu, S., et al. Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK Oncogene 23, 4984-4992 (2004).