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Azido-PEG9-amine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Azido-PEG9-amine图片
CAS NO:1207714-69-9
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1 g电议

产品介绍
Azido-PEG9-amine 是一种不可降解 (non-cleavable) 的 9 单元 PEG-ADC 连接物,用于抗体偶联药物 (ADC) 的合成。Azido-PEG9-amine 也是一种基于 PEG 的 PROTAC linker,可用于 PROTAC 的合成。
生物活性

Azido-PEG9-amine is anon-cleavable9 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs). Azido-PEG9-amine is also a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs[1].

IC50& Target[1]

Non-cleavable

 

PEGs

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

分子量

482.57

性状

Liquid

Formula

C20H42N4O9

CAS 号

1207714-69-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month