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4-hydroxy Alternariol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-hydroxy Alternariol图片
CAS NO:959417-21-1
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议

产品介绍
Cas No.959417-21-1
别名4-羟基格链孢酚
化学名3,4,7,9-tetrahydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one
Canonical SMILESCC1=C(C2=C(C(O3)=O)C(O)=CC(O)=C2)C3=C(O)C(O)=C1
分子式C14H10O6
分子量274.2
溶解度DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol formed through cytochrome P450 (CYP450) metabolism. It increases reactive oxygen species (ROS) in KYSE510 human esophageal cells by 701% compared to control. 4-hydroxy Alternariol increases topoisomerase IIβ-DNA complexes by 208% compared to control in an ICE assay but does not induce DNA damage in KYSE510 cells. It completely inhibits topoisomerase IIα activity at a concentration of 25 uM under cell-free conditions.