1-Deoxysphinganine (m18:0) (ES-285) 是一种海洋来源的抗增殖（抗肿瘤）化合物。 1-Deoxysphinganine (m18:0) 通过细胞内神经酰胺积累和 PKC&zeta 抑制前列腺 PC-3 和 LNCaP 细胞的生长；激活。
| Cas No. | 196497-48-0 |
| 别名 | ES-285 |
| 化学名 | 2S-amino-3R-octadecanol |
| Canonical SMILES | CCCCCCCCCCCCCCC[C@@H](O)[C@H](C)N |
| 分子式 | C18H39NO |
| 分子量 | 285.5 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 2 mg/mL,Ethanol: miscible |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 1-Deoxysphinganine is an atypical sphingolipid that lacks the C1-hydroxyl group of canonical sphinganine and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis. Plasma levels of 1-deoxysphinganine are increased in patients with hereditary sensory and autonomic neuropathy type 1 (HSAN1), an inherited neuropathy associated with serine palmitoyltransferase gene mutations, and in patients with glycogen storage disease type I (GSDI). Deoxysphingolipids, including 1-deoxysphinganine, are not converted to canonical sphingolipids or fatty acids and accumulate in cells, particularly in the mitochondria where 1-deoxysphinganine induces mitochondrial fragmentation and dysfunction. It also accumulates in LLC-PK1 cells and in mouse liver and kidney following application or administration, respectively, of the ceramide synthase inhibitor fumonisin B1 . 1-Deoxysphinganine is neurotoxic to dorsal root ganglion neurons in vitro, decreasing neurite length and inducing neurite contraction when used at a concentration 1 uM. It is cytotoxic to DU145 cells (IC50 = ~2 uM) but stimulates DNA synthesis in Swiss 3T3 cells when used at a concentration of 1 uM. |
m.cnreagent.com