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Digoxigenin Monodigitoxoside
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Digoxigenin Monodigitoxoside图片
CAS NO:5352-63-6
包装与价格:
包装价格(元)
500μg电议
1mg电议

产品介绍
Digoxigenin monodigitoxoside 是 Na+/K+ ATPase 抑制剂和地高辛的强心苷代谢物。
Cas No.5352-63-6
别名地高辛杂质D
化学名(3β,5β,12β)-3-[(2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-card-20(22)-enolide
Canonical SMILESC[C@@]12[C@@](CC[C@]3([H])[C@]2([H])C[C@@H](O)[C@@]4(C)[C@]3(O)CC[C@@H]4C(CO5)=CC5=O)([H])C[C@@H](O[C@]6([H])O[C@H](C)[C@@H](O)[C@@H](O)C6)CC1
分子式C29H44O8
分子量520.7
溶解度DMSO: slighly soluble,Methanol: slighly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 Digoxigenin monodigitoxoside is a Na+/K+-ATPase inhibitor and cardiac glycoside metabolite of digoxin . It has a binding affinity of 0.829 and an inhibitory potency of 1.07 relative to [3H]ouabain in a competitive binding assay using purified lamb Na+/K+-ATPase and for its ATPase activity, respectively. Digoxigenin monodigitoxoside is selective for the α3β1 isoform over α1β1 and α2β1 (Kds = 31.8, 65, and 35 nM, respectively). Digoxigenin monodigitoxoside produces a more potent inotropic response in perfused guinea pig hearts than digoxin with 60 and 46% increases in inotropy, respectively.