Bis-PEG8-acid is a PEG-basedPROTAClinkercan be used in the synthesis ofPROTACs. Bis-PEG8-acid is acleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

470.51

Solid

C₂₀H₃₈O₁₂

1246189-43-4

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