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PF 04418948
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
PF 04418948图片
CAS NO:1078166-57-0
包装与价格：
包装价格(元)
10mg电议
50mg电议
500mg电议
1g电议

产品介绍
PF 04418948 是一种口服有效的选择性前列腺素 EP2 受体拮抗剂，IC50 为 16 nM。
Cas No.1078166-57-0
化学名1-(4-fluorobenzoyl)-3-(((6-methoxynaphthalen-2-yl)oxy)methyl)azetidine-3-carboxylic acid
Canonical SMILESFC1=CC=C(C=C1)C(N2CC(COC3=CC=C4C(C=CC(OC)=C4)=C3)(C(O)=O)C2)=O
分子式C23H20FNO5
分子量409.41
溶解度<0.834mg/mL in EtOH, Limited solubility in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PF-04418948 is an orally active, potent and selective prostaglandin EP2 receptor antagonist with an IC50 of 16 nM.

References:
[1]. af Forselles KJ, et al. In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist. Br J Pharmacol. 2011 Dec;164(7):1847-1856.
[2]. Birrell MA, et al. Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor. Br J Pharmacol. 2013 Jan;168(1):129-138.