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Ro 67-7476
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ro 67-7476图片
CAS NO:298690-60-5
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Ro 67-7476 是一种有效的 mGluR1 正变构调节剂，可在表达大鼠 mGluR1a 的 HEK293 细胞中增强谷氨酸诱导的钙释放，EC50 为 60.1 nM。 Ro 67-7476 是一种有效的 P-ERK1/2 激动剂，在没有外源添加的谷氨酸 (EC50=163.3 nM) 的情况下激活 ERK1/2 磷酸化。
Cas No.298690-60-5
化学名(S)-2-(4-fluorophenyl)-1-tosylpyrrolidine
Canonical SMILESFC1=CC=C(C=C1)[C@H](CCC2)N2S(=O)(C3=CC=C(C)C=C3)=O
分子式C17H18FNO2S
分子量319.39
溶解度DMSO: 30 mg/ml
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. Displays no activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.target: mGlu1 EC 50: 60.1 nM(1) Ro 67-7476 (10 μM) can directly block the GIRK channel (to 67 ± 2% of control). (2) Ro 67-7476 enhance the glutamate-induced current in all chimeric receptors containing the transmembrane (TM) region of rmGlu1a (R1, R1-R5N, R1-R5C, and R5-R1TM) but not in those containing the TM region of rmGlu5a (R5, R5-R1N, R5-R1C, and R1-R5TM.(3) The application of Ro 67-7476 (3 μM) produced no effect alone but resulted in a marked potentiation of the mGlu1 EPSC amplitude.

References:
[1]. Hemstapat K et al. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol Pharmacol. 2006 Aug, 70(2), 616-26
[2]. Knoflach F et al. Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13402-7.