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Nobiletin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nobiletin图片
CAS NO:478-01-3
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)402.39
FormulaC21H22O8
CAS No.478-01-3
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 81 mg/mL (201.3 mM)
Water:<1 mg/mL
Ethanol: 3 mg/mL (7.5 mM)
SMILESO=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C1C(OC)=C(OC)C(OC)=C3OC
SynonymsNobiletin; Hexamethoxyflavone; NOB; 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one

Chemical Name: 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one

InChi Key: MRIAQLRQZPPODS-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3

实验参考方法
In Vitro

In vitro activity: Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities. Nobiletin, a polymethoxyflavonoid, is identified as an inhibitor of both NO and O 2- generation. Nobiletin significantly inhibites two skin inflammation induced by double TPA application. It also suppresses the expression of cyclooxygenase-2 and inducible NO synthase proteins and prostaglandin E2 release. Nobiletin inhibites the tumor-invasive activity of human fibrosarcoma HT-1080 cells in the Matrigel model, not only by suppressing the expression of MMPs but also augmenting TIMP-1 production through interfering the phosphatidylinositol 3-kinase pathway (PI3-K). Nobiletin may also prevent atherosclerosis at the level of the vascular wall by inhibiting macrophage foam-cell formation.


Kinase Assay: Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, has anti-inflammatory and anti-tumor activities. Nobiletin is able to suppress tumor growth, invasion, proliferation, and metastasis in vitro and in animal studies. Nobiletin was also found to potentially inhibit cartilage degradation. In human nasopharyngeal carcinoma cell lines (HONE-1 and NPC-BM), nobiletin treatment significantly inhibited cells invasion via inhibiting the phosphorylation of ERK1/2. When tested with rat C6 glioma cell, nobiletin was shown to inhibit cell proliferation via suppress ERK activity.


Cell Assay: Nobiletin is shown to have the ability to suppress tumor growth and metastasis. In human nasopharyngeal carcinoma cell lines (HONE-1 and NPC-BM), nobiletin treatment significantly inhibited cells invasion via inhibiting the phosphorylation of ERK1/2 [2]. When tested with rat C6 glioma cell, nobiletin was shown to inhibit cell proliferation via suppress ERK activity.

In VivoIn mouse model with 5-min BCCAO-induced brain ischemia, treatment nobiletin (50 mg/kg) intraperitoneally for the consecutive 7 days significantly inhibited delayed neuronal death in the hippocampal CA1 neurons and improved contextual memory. In MPTP-induced Parkinson mouse model, administration of Nobiletin (50mg/kg i.p.) intraperitoneally for 2 consecutive weeks improved motor and cognitive deficits.
Animal modelMouse
Formulation & Dosage50 mg/kg; i.p. injection
ReferencesCancer Res. 2000 Sep 15;60(18):5059-66; Cancer Res. 2002 Feb 15;62(4):1025-9.