Nenocorilant (Relacorilant) is a potent, orally activityglucocorticoid receptor(GR)antagonist with K_ivalue of 0.15 nM. Nenocorilant haspro-apoptoticeffects and improves potency combined with cytotoxic agent. Nenocorilant can be used forcancerresearch^[1][2][3].

Ki: 0.15 nM (glucocorticoid receptor)^[1]

Nenocorilant (Relacorilant) (0-1000 nM; 0-72 h; OvCa cells) has pro-apoptotic effects and reverses the effects of cortisol and partially restored Paclitaxel and Gemcitabine induction of tumor-cell apoptosis^[1].
Nenocorilant (Relacorilant) (100 nM; 4 h; MIA PaCa-2 and OVCAR5 cells) prevents dex-mediated upregulation of both GR target genesSGK1andMKP1^[2].

Nenocorilant (Relacorilant) (30 mg/kg; p.o.; once every four days, for 25 d; female Balb/c nude mice) improves the efficacy and promotes apoptotic activity of cytotoxic therapy in xenograft models under physiological cortisol conditions^[1].

587.55

C₂₆H₂₁F₄N₇O₃S

1496509-78-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.