Dynorphin A TFA

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Dynorphin A TFA

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

强啡肽A 三氟乙酸

产品介绍

Dynorphin A TFA 是一种内源性阿片肽，参与中枢神经系统 (CNS) 的抑制性神经传递。Dynorphin A TFA 是一种高效的 kappa 阿片受体 (KOR) 激动剂，也是其他阿片受体的激动剂，如 mu (MOR) 和 delta (DOR)。Dynorphin A TFA 可诱导神经元死亡，可用于神经系统疾病的相关研究。

生物活性

Dynorphin A TFA is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A TFA is a highy potentkappaopioid receptor(KOR)agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A TFA can induce neuronal death, and can be used in the research ofneurological disease^[1]^[2].

IC₅₀& Target^[3]

Human Endogenous Metabolite

Caspase-3

κ Opioid Receptor/KOR

体外研究
(In Vitro)

Dynorphin A TFA (10 μM, 4 h/72 h) increases caspase-3 activity and the level of cytochrome c released from mitochondria in mouse striatal neurons, and induces neuronal death^[3].
dynorphin A TFA (33 μM, 4 h) elevates [Ca²⁺]_iand causes a significant loss of neurons^[4].
dynorphin A TFA (1 μM) inhibits the release of vasopressin (VP) from the isolated neural lobe^[5].

Cell Viability Assay^[3]

Cell Line:	Mouse striatal neurons
Concentration:	10 μM
Incubation Time:	0, 24, 48, 72 h
Result:	Induced neuronal death (identified by the fragmentation and destruction of the cell body and neurites).

体内研究
(In Vivo)

Dynorphin A TFA (intracerebroventricular injection, 1 μg of 2 μL, a single dose) inhibits vasopressin (VP) release in 24 h water-deprived male rats^[5].
Dynorphin A TFA (intracerebroventricular injection, 500 pmol/5 μL per day for 4 d) alleviates stress-induced behavioral impairments in ddY mice accompanied by regulation of the 5-HTergic system in the brain^[6].

Animal Model:	24 h water-deprived male rats^[5]
Dosage:	1 μg of 2 μL
Administration:	Intracerebroventricular injection
Result:	Inhibited vasopressin (VP) release 30 min upon injection.

Animal Model:	Male ddY mice^[6]
Dosage:	15, 150, 1500 pmol/5 μL per day for 4 days
Administration:	Intracerebroventricular injection
Result:	Attenuated the repeated stress-induced escape failures from the shock.

分子量

2261.50

Formula

C₁₀₁H₁₅₆F₃N₃₁O₂₅

Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln

Sequence Shortening

YGGFLRRIRPKLKWDNQ

中文名称

强啡肽A 三氟乙酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.