Belotecan hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

213819-48-8

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

CKD-602

产品介绍

Belotecan hydrochloride (CKD-602 hydrochloride) 是拓扑异构酶 I (Topoisomerase I) 抑制剂，是一种合成的喜树碱衍生物。

生物活性

Belotecan hydrochloride (CKD-602 hydrochloride), aTopoisomeraseIinhibitor, is a synthetic camptothecin derivative.

IC₅₀& Target^[1]

Top1

体外研究
(In Vitro)

Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC₅₀values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells^[1]. Belotecan shows a significant anticancer effect on glioma cells, with IC₅₀values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG^[2].

体内研究
(In Vivo)

Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group^[3].

Clinical Trial

分子量

469.96

性状

Solid

Formula

C₂₅H₂₈ClN₃O₄

CAS 号

213819-48-8

中文名称

盐酸贝洛替康

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 12.5 mg/mL(26.60 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.1278 mL	10.6392 mL	21.2784 mL
5 mM	0.4256 mL	2.1278 mL	4.2557 mL
10 mM	0.2128 mL	1.0639 mL	2.1278 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。