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Roslin 2 bromide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Roslin 2 bromide图片
CAS NO:29574-21-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Benzylhexamethylenetetramine bromide
产品介绍
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) 是一种具有抗癌作用的p53再激活剂。Roslin 2 bromide 结合 FAK,破坏 FAK 和 p53 的结合。
生物活性

Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is ap53reactivator with anticancer effects. Roslin 2 bromide bindsFAK, disrupts the binding ofFAKand p53[1].

体外研究
(In Vitro)

Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner. Roslin 2 bromide increases p53 transcriptional activity that is inhibited by FAK using p21, Mdm-2, and Bax-promoter targets. Roslin 2 bromide also causes increased expression of p53 targets: p21, Mdm-2 and Bax proteins[1].

体内研究
(In Vivo)

Roslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53+/+but not in HCT116 p53-/-xenografts in vivo[1].

分子量

311.22

Formula

C13H19BrN4

CAS 号

29574-21-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.