CAS NO: | 29574-21-8 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is ap53reactivator with anticancer effects. Roslin 2 bromide bindsFAK, disrupts the binding ofFAKand p53[1]. |
体外研究 (In Vitro) | Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner. Roslin 2 bromide increases p53 transcriptional activity that is inhibited by FAK using p21, Mdm-2, and Bax-promoter targets. Roslin 2 bromide also causes increased expression of p53 targets: p21, Mdm-2 and Bax proteins[1]. |
体内研究 (In Vivo) | Roslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53+/+but not in HCT116 p53-/-xenografts in vivo[1]. |
分子量 | 311.22 |
Formula | C13H19BrN4 |
CAS 号 | 29574-21-8 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |