GSK2983559 free acid

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1579965-12-0

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议

产品介绍

GSK2983559 free acid (compound 3) 是一种具有口服活性且高效的受体相互作用蛋白 2 (RIP2) 激酶抑制剂。GSK2983559 free acid 在体内和人类炎症性肠病外植体样本中可阻断多种促炎细胞因子反应活性。

生物活性

GSK2983559 free acid (compound 3) is an orally active and potentreceptor interacting protein 2(RIP2) kinase inhibitor. GSK2983559 free acid can block many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples^[1].

IC₅₀& Target^[1]

RIPK2

体外研究
(In Vitro)

GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells^[2].

Cell Viability Assay^[2]

Cell Line:	THP-1 cells
Concentration:	1-1024 nM
Incubation Time:	2 hours
Result:	Inhibited IL-8 production with an IC₅₀of 1.34 nM.

体内研究
(In Vivo)

GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse^[2].

Animal Model:	C57BL/6 mice (female) injected with MDP (100 μg)^[2]
Dosage:	3 and 10 mg/kg
Administration:	Oral gavage; 3 and 10 mg/kg; once
Result:	Suppressed serum IL-6 levels in a dose-dependent manner.

Clinical Trial

分子量

538.53

性状

Solid

Formula

C₂₁H₂₃N₄O₇PS₂

CAS 号

1579965-12-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 5 mg/mL(9.28 mM;ultrasonic and warming and heat to 80℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.8569 mL	9.2845 mL	18.5691 mL
5 mM	0.3714 mL	1.8569 mL	3.7138 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。