CAS NO: | 896731-82-1 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
生物活性 | Conatumumab (AMG 655) is a human monoclonal agonist antibody against humandeath receptor 5(DR5, TRAILR2)(Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab inducesapoptosisviacaspaseactivation. Conatumumab can be used in the research of cancers.[1][2][3]. | ||||||||
IC50& Target | IC50: DR5 (<1 nm)[2] | ||||||||
体外研究 (In Vitro) | Conatumumab (0-10 μg/mL,4 小时) 激活 Colo205、H-2122 和 MiaPaCa2 细胞中的 caspase-3/7[2]。 Cell Viability Assay[2]
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体内研究 (In Vivo) | Conatumumab (0-100 μg,腹腔注射,每周两次) 抑制 Colo205、H2122 或 MiaPaCa2/T2 异种移植肿瘤的小鼠的肿瘤生长[2]。
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分子量 | 145.65 (kDa) | ||||||||
CAS 号 | 896731-82-1 | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |