Aurora kinase-IN-1 (Compound 9) is a potent inhibitor ofaurora kinase. Aurora kinase-IN-1 upregulates the expression of G1 cell cycle inhibitory proteins including p21 and p27, and G1 progressive cyclin D1, and downregulates G1-to-S progressive cyclins, resulting in cell cycle arrest at the G1/S boundary. Aurora kinase-IN-1 also inducesapoptosis. Aurora kinase-IN-1 is a lead compound for chemotherapeutic agents^[1].

667.34

C₃₀H₂₅Br₂N₃O₅

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