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SNS-314
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SNS-314图片
CAS NO:1057249-41-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
SNS-314 是一种有效的选择性极光激酶 (aurora) 抑制剂,对极光激酶 A,B,C 的IC50值分别为 9,31 和 6 nM。
生物活性

SNS-314 is a potent and selectiveaurorakinase inhibitor withIC50s of 9, 31, and 6 nM foraurora A, B and C, respectively[1].

IC50& Target[1]

Aurora A

9 nM (IC50)

Aurora B

31 nM (IC50)

Aurora C

6 nM (IC50)

体外研究
(In Vitro)

SNS-314 blocks proliferation in a broad panel of tumor cell lines (HCT116, A2780, PC-3, HeLa, MDA-MB-231, H-1299, and HT29) with IC50values ranging from 1.8 nM in A2780 ovarian cancer cells to 24 nM in HT29 colon cancer cells[2].

体内研究
(In Vivo)

In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off[2].

Clinical Trial
分子量

430.93

Formula

C18H15ClN6OS2

CAS 号

1057249-41-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.