CAS NO: | 1057249-41-8 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | SNS-314 is a potent and selectiveaurorakinase inhibitor withIC50s of 9, 31, and 6 nM foraurora A, B and C, respectively[1]. | |||
IC50& Target[1] |
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体外研究 (In Vitro) | SNS-314 blocks proliferation in a broad panel of tumor cell lines (HCT116, A2780, PC-3, HeLa, MDA-MB-231, H-1299, and HT29) with IC50values ranging from 1.8 nM in A2780 ovarian cancer cells to 24 nM in HT29 colon cancer cells[2]. | |||
体内研究 (In Vivo) | In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off[2]. | |||
Clinical Trial | ||||
分子量 | 430.93 | |||
Formula | C18H15ClN6OS2 | |||
CAS 号 | 1057249-41-8 | |||
运输条件 | Room temperature in continental US; may vary elsewhere. | |||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |