CAS NO: | 1028486-06-7 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Alisertib (MLN 8237) sodium is an orally active and selectiveAurora Akinaseinhibitor (IC50=1.2 nM), which binds toAurora Akinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib sodium inducesapoptosisandautophagythrough targeting theAKT/mTOR/AMPK/p38pathway in leukemic cells. Antitumor activity[1][2][3]. | ||||||||
IC50& Target[3] |
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体外研究 (In Vitro) | Alisertib (MLN 8237) leads the MM cells to mitotic spindle abnormalities, mitotic accumulation, as well as inhibition of cell proliferation through apoptosis and senescence. Alisertib up-regulates p53 and tumor suppressor genes p21 and p27[1]. | ||||||||
体内研究 (In Vivo) | Alisertib (MLN 8237) (30 mg/kg, p.o.) significantly reduces tumor burden and increases overall survival in xenograft-murine model of human-MM[1].
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Clinical Trial | |||||||||
分子量 | 540.91 | ||||||||
Formula | C27H19ClFN4NaO4 | ||||||||
CAS 号 | 1028486-06-7 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |