CAS NO: | 551919-98-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | GW779439X is a pyrazolopyridazine identified in an inhibitor of theS. aureusPASTA kinaseStk1. GW779439X potentiates the activity of β-lactamantibioticsagainst various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is anAURKAinhibitor and inducesapoptosisby the caspases 3/7 pathway[1][2]. MRSA:methicillin-resistantS. aureus; MSSA: methicillin-sensitiveS. aureus | ||||||||||||||||
IC50& Target[1][2] |
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体外研究 (In Vitro) | GW779439X (2 μM) biochemically inhibits Stk1. GW779439X (5 μM) potentiates ceftaroline activity against a ceftaroline-resistant MRSA strain. GW779439X is able to potentiate the activity of oxacillin against various S. aureus isolates, including both MRSA and MSSA isolates, but the potentiation is clearly strongest in PBP2A-containing strains[1]. | ||||||||||||||||
分子量 | 454.45 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C22H21F3N8 | ||||||||||||||||
CAS 号 | 551919-98-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 31.25 mg/mL(68.76 mM;Need ultrasonic) 配制储备液
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