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Orobol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Orobol图片
CAS NO:480-23-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Orobol 是一种主要的大豆异黄酮,具有多种药理活性,包括抗皮肤老化和抗肥胖作用。Orobol 抑制CK1ε、VEGFR2、MAP4K5、MNK1、MUSK、TOPK 和 TNIK (IC50=1.24-4.45 μM)。Orobol 还抑制 PI3K 亚型 (对于 PI3K α/β/γ/K/δ,IC50=3.46-5.27μM)。
生物活性

Orobol is one of the major soyisoflavonesand has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibitsCK1ε, VEGFR2, MAP4K5,MNK1, MUSK,TOPK, and TNIK (IC50=1.24-4.45 μM). Orobol also inhibitsPI3Kisoforms (IC50=3.46-5.27 μM forPI3Kα/β/γ/K/δ)[1][2].

体外研究
(In Vitro)

Orobol binds to CK1ε in an ATP-competitive manner and exerts anti-obesity effects by targeting casein kinase 1 epsilon[2].
Orobol (5-20 μM) effectively suppresses MDI (isobutylmethylxanthine, dexamethasone and insulin (MDI))-induced phosphorylation of 4E-BP1[2].

体内研究
(In Vivo)

Orobol attenuates high fat diet-induced weight gain and lipid accumulation without affecting food intake in C57BL/6J mice[2].

Animal Model:HFD-induced obesity in C57BL/6J mice[2]
Dosage:10 mg/kg
Administration:Intragastrically; daily for 23 weeks
Result:Significantly reduced body weight by 17.3% compared to the HFD group.
分子量

286.24

Formula

C15H10O6

CAS 号

480-23-9

结构分类
  • Flavonoids
  • Isoflavones
  • Phenols
  • Polyphenols
来源
  • Plants
  • Leguminosae
  • Glycine max(L.) merr
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.