CAS NO: | 36945-98-9 |
包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
10mg | 电议 |
50mg | 电议 |
Cas No. | 36945-98-9 |
别名 | AG-3-5 |
化学名 | 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one |
Canonical SMILES | C1C=C(NC(=O)N1C2=CC=CC=C2O)C3=CC(=CC=C3)[N+](=O)[O-] |
分子式 | C16H13N3O4 |
分子量 | 311.29 |
溶解度 | ≥ 11.05mg/mL in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Icilin is an agonist of TRPM8 and hENaCδ [1, 2] Icilin is a synthetic supercooling compound. It is reported that icilin can activate TRPM8 to some small degree in the absence of extra-cellular Ca2+. It further enhances the potency of icilin and the subsequent activation of TRPM8 channel. Icilin is also an agonist of hENaCδ. In the homomeric hENaCδ-expressing oocytes, 100μM icilin induces an inward current significantly. This effect can be reduced when the external Na+ is removed. In addition, icilin shows anti-proliferation efficacy in PC-3 cells. It induces G1 arrest via modulating the expression of cell cycle regulators including cyclin A, cyclin D1, CDK1 and CDK2. Icilin plays this role without affecting TRPM8 but through activating NK and p38 kinase pathways [1, 2 and 3] References: |