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Icilin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Icilin图片
CAS NO:36945-98-9
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
50mg电议

产品介绍
Icilin (AG-3-5) 是瞬时受体电位 M8 (TRPM8) 离子通道的超级激动剂。
Cas No.36945-98-9
别名AG-3-5
化学名3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one
Canonical SMILESC1C=C(NC(=O)N1C2=CC=CC=C2O)C3=CC(=CC=C3)[N+](=O)[O-]
分子式C16H13N3O4
分子量311.29
溶解度≥ 11.05mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Icilin is an agonist of TRPM8 and hENaCδ [1, 2]

Icilin is a synthetic supercooling compound. It is reported that icilin can activate TRPM8 to some small degree in the absence of extra-cellular Ca2+. It further enhances the potency of icilin and the subsequent activation of TRPM8 channel. Icilin is also an agonist of hENaCδ. In the homomeric hENaCδ-expressing oocytes, 100μM icilin induces an inward current significantly. This effect can be reduced when the external Na+ is removed. In addition, icilin shows anti-proliferation efficacy in PC-3 cells. It induces G1 arrest via modulating the expression of cell cycle regulators including cyclin A, cyclin D1, CDK1 and CDK2. Icilin plays this role without affecting TRPM8 but through activating NK and p38 kinase pathways [1, 2 and 3]

References:
[1] Chuang H, Neuhausser W M, Julius D. The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron, 2004, 43(6): 859-869.
[2] Yamamura H, Ugawa S, Ueda T, et al. Icilin activates the δ-subunit of the human epithelial Na+ channel. Molecular pharmacology, 2005, 68(4): 1142-1147.
[3] Kim S H, Kim S Y, Park E J, et al. Icilin induces G1 arrest through activating JNK and p38 kinase in a TRPM8-independent manner. Biochemical and biophysical research communications, 2011, 406(1): 30-35.