| CAS NO: | 309-29-5 |
| 包装: | 50mg |
| 市场价: | 525元 |
| Cas No. | 309-29-5 |
| 别名 | 多沙普仑 |
| 化学名 | 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one |
| Canonical SMILES | CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4 |
| 分子式 | C24H30N2O2 |
| 分子量 | 378.51 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Doxapram is a strong, dose-dependent respiratory stimulant in mammals. The oral LD50 in rats is 211mg/kg [1]. After Doxapram treatment, it has been noted a pressor response action through stimulation of the central nervous system (CNS). In addition, Doxapram has shown not only the central sensitization but also the prtipheral sensitization to hypercarbia in both animal and human studies. Furthermore, Doxapram has been reported to stimulate the carotid body in a dose-dependent fashion and have an additive but not synergistic effect on the carotid body response to hupercapnia. Apart from these, Doxapram has also shown the potent, direct and inhibitory effects on cloned TASK-1 and TASK-3 channels with the EC50 values of 410nM, 37nM and 9nM for TASK-1, TASK-3 and TASK-1/TASK-3, respectively. Doxapram has been revealed to augment neuromuscular transmission in a dose-related manner above a threshold concentration of 50μM [1]. References: |
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