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Sotalol hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sotalol hydrochloride图片
CAS NO:959-24-0
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议
100mg电议
200mg电议

产品介绍

β-adrenergic receptor antagonist

Cas No.959-24-0
别名盐酸索他洛尔; MJ 1999
化学名N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide;hydrochloride
Canonical SMILESCC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.Cl
分子式C12H21ClN2O3S
分子量308.82
溶解度≥ 15.441mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sotalol hydrochloride is a potent and non-selective antagonist of β-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

As a class III antiarrhythmic drug, Sotalol hydrochloride has been reported to increase the functional refractory period without reducing conduction velocity, using an in vitro experimental rabbit heart model of reentrant tachycardia. In vivo, Sotalol hydrochloride has shown to lengthen atrial and ventricular monophasic action potential duration in the intact dog heart during constant atrial pacing [2].Besides, Sotalol is a β-adrenergic receptor blocker commonly used in rhythm-control treatment of AF (Atrial fibrillation) [3].

References:
[1] Vormberge T1, Hoffmann M, Himmel H. Safety pharmacology assessment of drug-induced QT-prolongation in dogs with reduced repolarization reserve. J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):130-40. Epub 2006 Apr 25.
[2] Claudel JP1, Touboul P. Sotalol: from "just another beta blocker" to "the prototype of class III antidysrhythmic compound".Pacing Clin Electrophysiol. 1995 Mar;18(3 Pt 1):451-67.
[3] Sicouri S1, Pourrier M, Gibson JK, Lynch JJ, Antzelevitch C. Comparison of electrophysiological and antiarrhythmic effects of vernakalant, ranolazine, and sotalol in canine pulmonary vein sleeve preparations. Heart Rhythm. 2012 Mar;9(3):422-9.