CK2 inhibitor 3

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CK2 inhibitor 3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

CK2 inhibitor 3 是一种有效的CK2抑制剂，IC₅₀为 280 nM。CK2 inhibitor 3 可抑制细胞内的 CK2，显著影响肿瘤细胞的活力，并对一组 320 激酶显示出显著的选择性。

生物活性

CK2 inhibitor3 is a potentCK2inhibitor withIC₅₀value of 280 nM.CK2 inhibitor3 inhibits endocellularCK2, significantly affects viability of tumour cells and shows remarkable selectivity on a panel of 320 kinases^[1].

IC₅₀& Target^[1]

CK2

280 nM (IC₅₀)

体外研究
(In Vitro)

CK2 inhibitor 3 (compound 4) (0-50 μM; 24 hours) significantly reduces cell viability in a dose-dependent manner, and DC₅₀value is 12.80 μM^[1].
CK2 inhibitor 3 (5 μM and 20 μM; 16 hours) decreases the CK2-dependent phospho-site Akt Ser129 level^[1].

Cell Viability Assay

Cell Line:	Jurkat cells^[1]
Concentration:	0 μM, 10 μM, 20 μM, 30 μM, 40 μM and 50 μM
Incubation Time:	24 hours
Result:	Significantly reduced cell viability in a dose-dependent manner, and DC₅₀value was 12.80 μM.

Western Blot Analysis

Cell Line:	Jurkat cells^[1]
Concentration:	5 μM and 20 μM
Incubation Time:	16 hours
Result:	Decreased the CK2-dependent phospho-site Akt Ser129 level.

分子量

381.20

Formula

C₁₃H₉BrN₄O₃S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.