NU2058 (O6-(Cyclohexylmethyl)guanine) is a potent, competitive and guanine-basedCDKinhibitor withIC₅₀s of 17 μM and 26 μM forCDK2andCDK1. NU2058 has anti-cancer activity.

NU2058 (O6-(Cyclohexylmethyl)guanine) is a competitive inhibitor of CDK2 with respect to ATP (Ki value CDK2, 12 μM) that binds in the ATP binding pocket in a different orientation from other purine-based inhibitors, including olomoucine and roscovotine. NU2058 is the lead compound in a structure-based drug discovery program to develop more potent and selective CDK inhibitors.

247.30

Solid

C₁₂H₁₇N₅O

161058-83-9

O6-环甲基己基鸟嘌呤

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 32 mg/mL(129.40 mM)

*"≥" means soluble, but saturation unknown.

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储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。