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S0859
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
S0859图片
CAS NO:1019331-10-2
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议
200mg电议

产品介绍
S0859 是一种选择性、高亲和力的通用 Na+/HCO3- 转运蛋白 (NBC) 抑制剂。
Cas No.1019331-10-2
别名NBC抑制剂(S0859),S 0859;S-0859
化学名2-chloro-N-((2'-(N-cyanosulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(4-methylbenzyl)benzamide
Canonical SMILESCC1=CC=C(CN(C(C2=CC=CC=C2Cl)=O)CC3=CC=C(C4=CC=CC=C4S(=O)(NC#N)=O)C=C3)C=C1
分子式C29H24ClN3O3S
分子量530.04
溶解度DMF: 50 mg/mL,DMSO: 30 mg/mL,Ethanol: 50 mg/mL,PBS (pH 7.2): 10 mg/mL
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

S0859 is a selective, high-affinity generic NBC inhibitor. S0859 reversibly inhibits NBC-mediated intracellular pH (pHi) recovery (Ki=1.7 μM, full inhibition at approximately 30 μM).

Treatment with NBC inhibitor S0859 significantly increased caspase-3 activity and elevated the number of apoptotic EC. S0859 is potentially important for probing the transporter's functional role in heart and other tissues[1].

References:
[1]. Larsen AM, Krogsgaard-Larsen N, Lauritzen G, et al. Gram-scale solution-phase synthesis of selective sodium bicarbonate co-transport inhibitor S0859: in vitro efficacy studies in breast cancer cells. ChemMedChem. 2012 Oct;7(10):1808-14.
[2]. Lauritzen G, Stock CM, Lemaire J, et al. The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2. Cancer Lett. 2012 Apr 28;317(2):172-83.
[3]. Kumar S, Flacke JP, Kostin S, et al. SLC4A7 sodium bicarbonate co-transporter controls mitochondrial apoptosis in ischaemic coronary endothelial cells. Cardiovasc Res. 2011 Feb 1;89(2):392-400.
[4]. Ch'en FF, Villafuerte FC, Swietach P, et al. S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart. Br J Pharmacol. 2008 Mar;153(5):972-82.