CDK9-IN-9 (example 2) is a potent and selectiveCDK9inhibitor with anIC₅₀of 1.8 nM. CDK9-IN-9 inhibitsCDK2with an IC₅₀of 155 nM. CDK9-IN-9 has anti-cancer activity^[1].

CDK9-IN-9 (example 2) inhibits the proliferation of HeLa, HeLa-MaTu-ADR, NCI-H460, DU145, Caco-2, B16F10, A2780 and MOLM-13 cells with IC₅₀s of 4.4 nM, 5.3 nM, 9.2 nM, 4.5 nM, 8.4 nM, 1.2 nM, 1.2 nM, 2.0 nM, respectively^[1].

459.51

C₂₂H₂₃F₂N₅O₂S

2246956-84-1

Room temperature in continental US; may vary elsewhere.

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