CDK2/4/6-IN-1

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CDK2/4/6-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2803837-13-8

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

CDK2/4/6-IN-1 (example 29) 是一种CDK2/4/6抑制剂，作用于 CDK2、CDK4、CDK6 的IC₅₀值分别是 2.5、23.7 和 44.3 nM。可用于癌症研究。

生物活性

CDK2/4/6-IN-1(example 29) is aCDK2/4/6inhibitor withIC₅₀values of 2.5, 23.7 and 44.3 nM forCDK2,CDK4andCDK6, respectively. CDK2/4/6-IN-1 can be used incancerresearch^[1].

IC₅₀& Target^[1]

CDK2

2.5 nM (IC₅₀)

CDK4

23.7 nM (IC₅₀)

CDK6

44.3 nM (IC₅₀)

体外研究
(In Vitro)

CDK2/4/6-IN-1(example 29) (0-600 nM, 24 h) inhibits the proliferation of OVCAR3 and MCF7 cells with the IC₅₀values of 14.6 and 117.8 nM, respectively^[1].
CDK2/4/6-IN-1(example 29) (0-600 nM, 24 h) inhibits phosphorylation of Rb protein in OVCAR3 and MCF7 cells with the IC₅₀values of 18 and 581 nM, respectively^[1].

体内研究
(In Vivo)

CDK2/4/6-IN-1(example 29) (25 mg/kg or 50 mg/kg, once a day, orally) has a significant inhibitory effect on tumor growth^[1].
The pharmacokinetic parameters of example 29 in BALB/c mice (10 mg/kg, p.o.)

Parameters	C_max(ng/mL)	T_max(hr)	AUC_last(hr*ng/mL)	T_1/2(hr)
PO	4050	0.5	10050	4.8

The pharmacokinetic parameters of example 29 in BALB/c mice (3 mg/kg, i.v.)

Parameters	C₀(ng/mL)	T_1/2(hr)	AUC_last(hr*ng/mL)	V_ss(L/Kg)
IV	4407	0.7	3245	0.9

分子量

438.50

Formula

C₂₂H₂₂N₄O₄S

CAS 号

2803837-13-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.