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CDK9-IN-14
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CDK9-IN-14图片
CAS NO:2650640-17-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CDK9-IN-14 是一种有效且具有选择性的CDK9抑制剂,IC50为 6.92 nM。CDK9-IN-14 对 MV4;11 细胞和体内肿瘤模型有较强的抑制作用,选择性好,毒性低,副作用少。
生物活性

CDK9-IN-14 is a potent and selectiveCDK9inhibitor withIC50of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells andin vivotumor models, and has a good selectivity and a low toxicity and few side effects[1].

IC50& Target[1]

CDK9

6.92 nM (IC50)

体外研究
(In Vitro)

CDK9-IN-14 (0-1000 nM) has strong inhibitory effect in MV4;11 cells with IC50= 34 nM[1].

体内研究
(In Vivo)

CDK9-IN-14 (5 mg/kg; p.o., qd, for 9 days) exhibits significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%[1].

Animal Model:Female Nu/Nu mice (6-8 weeks old, 18-22 g, injected with HL-60 cells)[1]
Dosage:5 mg/kg
Administration:p.o., qd, for 9 days
Result:Exhibited significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%.
分子量

419.42

Formula

C21H23F2N3O4

CAS 号

2650640-17-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.