Palifosfamide tromethamine

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1070409-31-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Isophosphoramide mustard tromethamine
IPM tromethamine
ZIO-201 tromethamine

产品介绍

Palifosfamide (tromethamine) 是一种具有潜在抗肿瘤活性的合成烷基化剂。作为异环磷酰胺 (ifosfamide) 稳定的活性代谢物，Palifosfamide (tromethamine) 通过GC碱基对不可逆地烷基化和交联DNA，导致了DNA复制的抑制，并最终导致细胞死亡。与异环磷酰胺相比，Palifosfamide (tromethamine)的毒性较小。

生物活性

Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.

Clinical Trial

分子量

342.16

Formula

C₈H₂₂Cl₂N₃O₅P

CAS 号

1070409-31-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.