Uridine 5'-diphosphate sodium salt 是一种有效的选择性P2Y6受体天然激动剂 (EC50=300 nM;pEC50=6.52)，也是一种有效的P2Y14拮抗剂 (pEC50=7.28)。Uridine 5'-diphosphate sodium salt 是一种内源性代谢产物 (endogenous metabolite)，可催化多种底物的葡糖醛酸糖化反应，可用于核酸生物合成 (RNA biosynthesis)。
| 生物活性 | Uridine 5'-diphosphate sodium salt is a potent, selectiveP2Y6receptor native agonist (EC50=300 nM;pEC50=6.52) and a potentP2Y14antagonist (pEC50=7.28). Uridine 5'-diphosphate sodium salt, anendogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used innucleic acid (RNA) biosynthesis[1][2]. |
| IC50& Target[1] | Human Endogenous Metabolite |
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体外研究
(In Vitro) | Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression[2].
Uridine 5'-diphosphate sodium salt (100 μM; 3 hours) induces chemokine expression in microglia[2].
Uridine 5'-diphosphate sodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2].
UDP (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2].
Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia[2].
RT-PCR[2] | Cell Line: | Primary microglia | | Concentration: | 100 μM | | Incubation Time: | For 15 min | | Result: | Significantly induced microglial CCL2 and CCL3 mRNA expression. |
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| 结构分类 | - Ketones, Aldehydes, Acids
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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