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Trelagliptin succinate(SYR-472)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Trelagliptin succinate(SYR-472)图片
CAS NO:1029877-94-8
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)475.47
FormulaC22H26FN5O6
CAS No.1029877-94-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 10 mM
Water: N/A
Ethanol: N/A
Solubility (In vivo)

Chemical Name: (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile succinate

InChi Key: OGCNTTUPLQTBJI-XFULWGLBSA-N

InChi Code: InChI=1S/C18H20FN5O2.C4H6O4/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20;5-3(6)1-2-4(7)8/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3;1-2H2,(H,5,6)(H,7,8)/t15-;/m1./s1

SMILES Code: O=C(O)CCC(O)=O.N#CC1=CC=C(F)C=C1CN(C(N2C)=O)C(N3C[C@H](N)CCC3)=CC2=O

SynonymsSYR-472; SYR472; SYR 472; SYR 472; Trelagliptin, Trelagliptin succinate; brand name: Zafatek.
实验参考方法
In Vitro

In vitro activity: Trelagliptin (also known as SYR-472) is a potent, highly selective, long-acting DPP-4 (dipeptidyl peptidase-4) inhibitor under development by Takeda for the treatment of type 2 diabetes (T2D).. Once-weekly Trelagliptin treatment produced clinically and statistically significant improvements in glycaemic control in patients with type 2 diabetes. It was well tolerated and might be a new treatment option for patients with this disease. Trelagliptin was approved in Japan for the treatment of type 2 diabetes mellitus (T2DM).

In VivoTrelagliptin improves glycaemic control by inhibition of DPP-4 activity.
Animal model
Formulation & Dosage
References

Lancet Diabetes Endocrinol. 2014 Feb;2(2):125-32.