包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | HDAC6/HSP90-IN-2 (compound 6e) is a dual inhibitor ofHDAC6andHsp90, withIC50s of 105.7 and 61 nM, respectively. HDAC6/HSP90-IN-2 can be used for the research ofcancer[1]. | ||||||||||||||||||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | HDAC6/HSP90-IN-2 (compound 6e) (0.05-2 μM; 24 h) effects HSP90, HDAC6 and signaling pathways regulated by Hsp90 dose-dependently[1].HDAC6/HSP90-IN-2 (compound 6e) (2 μM; 24 h) promotes the acetylation of HSP90[1].HDAC6/HSP90-IN-2 (compound 6e) (0-100 μM; 24-72 h) inhibits the growth of H1975 non-small cell lung cancer cells[1].HDAC6/HSP90-IN-2 (compound 6e) (0-2 μM; 24 h) induces apoptosis of H1975 cells[1]. Western Blot Analysis[1]
Western Blot Analysis[1]
Apoptosis Analysis[1]
Cell Viability Assay[1]
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体内研究 (In Vivo) | HDAC6/HSP90-IN-2 (25-50 mg/kg; i.p. every weekdays for 6 weeks) exhibits antitumor activity of in NOD-scid IL2Rgammanull (NSG) mice with xenotransplantation of H1975 cells[1].
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分子量 | 358.39 | ||||||||||||||||||||||||||||||||
Formula | C19H22N2O5 | ||||||||||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |