HDAC-IN-42 (compound 14f) is a potent and selectiveHDACinhibitor withIC₅₀values of 0.19 and 4.98 μM forHDAC1andHDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 inducesapoptosisand cell cycle arrest at G2/M phase^[1].

HDAC-IN-42 (compound 14f) shows anti-proliferative activity with C₅₀s of 9.56, 13.32, 10.46, 6.91 μM for MCF-7, HCT-116, HepG2, Hela cells, respectively^[1].
HDAC-IN-42 (1, 5, 10 μM; 24 h) reduces the colony formation and increases the expression of histone H3 and α-tubulin in HeLa cells^[1].
HDAC-IN-42 (1, 5, 10 μM; 48 h) induces apoptosis and cell cycle arrest at G2/M phase^[1].

381.34

C₂₀H₁₅NO₇

2454024-18-9

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