HDAC6-IN-15 是一种选择性组蛋白脱乙酰酶 6(HDAC6)抑制剂。HDAC6-IN-15 对 HDAC6 具有有效的抑制活性，IC50值为 38.2 nM。HDAC6-IN-15 可用于癌症和神经退行性疾病的研究。
| 生物活性 | HDAC6-IN-15 is a selectivehistone deacetylase 6 (HDAC6)inhibitor. HDAC6-IN-15 has potent inhibitory activity forHDAC6withIC50value of 38.2 nM. HDAC6-IN-15 can be used for the research ofcancerand neurodegenerative diseases[1]. |
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体外研究
(In Vitro) | HDAC6-IN-15 (Compound II-5) 对 HDAC6 具有有效的抑制活性，IC50值为 38.2 nM[1]。
HDAC6-IN-15 (50 μL; 48 h) 对 22RV1、MM1.S、MV4-11、JEKO-1 和 4T1 细胞具有抗肿瘤活性，IC50值分别为 8.90 μM、11.90 μM、7.83 μM、4.80 μM 和 16.51 μM[1]。
HDAC6-IN-15（100、200、400、800 nM；24 h）剂量依赖性地诱导乙酰化 a-微管蛋白的积累[1]。
HDAC6-IN-15 (5, 10 μM; 24 h) 可诱导细胞凋亡[1]。
HDAC6-IN-15（4 mg/mL；48 h）表现出最佳的人血浆稳定性特征[1]。
Cell Proliferation Assay[1] | Cell Line: | 22RV1, MM1.S, MV4-11, JEKO-1 and 4T1 cells | | Concentration: | 50 μL | | Incubation Time: | 48 h | | Result: | Showed moderate anti-proliferative activities in all the cancer cell lines. |
Western Blot Analysis[1] | Cell Line: | JEKO-1 cells; 4T1 cells | | Concentration: | 100, 200, 400, 800 nM; 5, 10 μM | | Incubation Time: | 24 h | | Result: | Significantly increase the levels of acetylated α-tubulin in a concentration dependent manner.
Slightly increased the levels of histone H3 and H4 acetylation.
Significantly increased the ratio of acetylated α-tubulin at the concentration of 800 nM.
Dramatically increased the levels of cleavage of PARP and caspase-3 in cells dose-dependently. |
Apoptosis Analysis[1] | Cell Line: | 4T1 cells | | Concentration: | 5, 10 μM | | Incubation Time: | 24 h | | Result: | Triggered apoptosis in 4T1 cells in a dose-dependent manner, in particularly undergoing early stage apoptosis upon 18 h treatment. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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