PARP-1/HDAC-IN-1 is aPARP-1/HDAC6dual targeting inhibitor withIC₅₀s of 68.90 nM and 510 nM, respectively. PARP-1/HDAC-IN-1 displays remarkable anticancer, anti-migration and anti-angiogenesis activities^[1].

PARP-1/HDAC-IN-1 (Compound 1–8-6) possesses potent inhibitory activity against MDA-MB-436, ES-2, DU145, A549, HCC1937, and Capan-1 cells with IC₅₀values of 0.35 μM, 1.16 μM, 3.38 μM, 5.67 μM, 2.85 μM, and 4.53 μM, respectively^[1].
PARP-1/HDAC-IN-1 (Compound 1–8-6; 0.3-10 μM) is able to heighten expression level of acetylated α-tubulin with marginal effects to acetylated histones H3 and H4^[1].

402.40

C₂₂H₁₈N₄O₄

Room temperature in continental US; may vary elsewhere.

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