c-Met/HDAC-IN-2 是一种高效的c-Met和HDAC双重抑制剂，对HDAC1与c-Met的IC50分别为 18.49 nM 和 5.40 nM。c-Met/HDAC-IN-2 对几种癌细胞具有抗增殖活性。c-Met/HDAC-IN-2 能将 HCT-116 细胞周期阻滞在 G2/M 期，诱导细胞凋亡 (apoptosis)。c-Met/HDAC-IN-2 可用于抗癌耐药研究。
| 生物活性 | c-Met/HDAC-IN-2 is a highly potentc-MetandHDACdual inhibitor withIC50s of 18.49 nM and 5.40 nM forHDAC1andc-Met, respectively. c-Met/HDAC-IN-2 has antiproliferative activities against certaincancercell lines. c-Met/HDAC-IN-2 can cause G2/M-phase arrest and induceapoptosisin HCT-116. c-Met/HDAC-IN-2 can be used for researching anti-cancer resistance[1]. |
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体外研究
(In Vitro) | c-Met/HDAC-IN-2 (compound 14X) (0-20 μM; 72 hours) exhibits antiproliferative activities against HCT-116, MCF-7 and A549[1].
c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) induces of cancer cell apoptosis in a dose-dependent manner[1].
c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) significantly causes G2/M-phase arrest in HCT-116 cells in a dose dependent manner[1].
Cell Proliferation Assay | Cell Line: | HCT-116, MCF-7 and A549[1] | | Concentration: | 0-20 μM | | Incubation Time: | 72 hours | | Result: | Exhibited antiproliferative activities against HCT-116, MCF-7 and A549 with IC50s of 0.22 ± 0.09 μM, 1.59 ± 0.06 μM and 0.22 ± 0.04 μM, respectively. |
Apoptosis Analysis | Cell Line: | HTC-116[1] | | Concentration: | 0.2, 1 and 5 μM | | Incubation Time: | 48 hours | | Result: | The percentage of apoptotic cells was 4.19%, 11.53% and 21.48% at 0.2 μM, 1.0 μM and 5.0 μM, respectively. |
Cell Cycle Analysis | Cell Line: | HTC-116[1] | | Concentration: | 0.2, 1 and 5 μM | | Incubation Time: | 48 hours | | Result: | Significantly caused G2/M-phase arrest in HCT-116 cells in a dose dependent manner. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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