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HDAC-IN-49
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
HDAC-IN-49图片
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
HDAC-IN-49 是一种有效的非选择性HDAC(HDAC) 抑制剂，对 HDAC1、HDAC2、HDAC3、HDAC4 和 HDAC6 的IC50分别为 13 nM、14 nM、21 nM、1880 nM 和 10 nM 。HDAC-IN-49 表现出显着的抗白血病活性， 但对健康细胞具有低细胞毒性。
生物活性

HDAC-IN-49 is a potent unselectiveHDAC(HDAC) inhibitor withIC50s of 13 nM, 14 nM, 21 nM, 1880 nM, and 10 nM forHDAC1,HDAC2,HDAC3,HDAC4, andHDAC6. HDAC-IN-49 demonstrates prominent antileukemic activity with low cytotoxic activity toward healthy cells[1].

IC50& Target[1]

HDAC1

13 nM (IC50)

HDAC2

14 nM (IC50)

HDAC3

21 nM (IC50)

HDAC4

1880 nM (IC50)

HDAC6

10 nM (IC50)

体外研究
(In Vitro)

HDAC-IN-49 (compound 10h) shows remarkable cytotoxic potential against different therapy-resistant leukemia cell lines, with IC50values of 0.375 μM, 0.218 μM, and 0.285 μM for HAL01, HL60 and Jurkat cells, respectively. HDAC-IN-49 (compound 10h; 1-5 μM; 48 h) treatment results in a significant apoptosis induction in HL60 cells[1].
HDAC-IN-49 (compound 10h; 6-36 μM; 24 h) shows a dose-dependent increase in the level of acetylation of α-tubulin and histone 3 (H3) in HL60 cells[1].

Apoptosis Analysis[1]

Cell Line:HL60 cells
Concentration:1 μM and 5 μM
Incubation Time:48 h
Result:Resulted in a significant apoptosis induction.

Western Blot Analysis[1]

Cell Line:HL60 cells
Concentration:6 μM, 12 μM, 24 μM, 36 μM
Incubation Time:24 h
Result:Increased in the level of acetylation of α-tubulin and histone 3 (H3).
分子量

478.52

Formula

C26H27FN4O4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.