HDAC1/MAO-B-IN-1

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HDAC1/MAO-B-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2759855-37-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

HDAC1/MAO-B-IN-1 是一种有效的、选择性的、可穿过血脑屏障的HDAC1/MAO-B抑制剂，IC₅₀值分别为 21.4 nM 和 99.0 nM。HDAC1/MAO-B-IN-1 具有阿尔茨海默病研究的潜力。

生物活性

HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrierHDAC1/MAO-Binhibitor withIC₅₀values of 21.4 nM and 99.0 nM forHDAC1andMAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease^[1].

IC₅₀& Target^[1]

HDAC1

21.4 nM (IC₅₀)

MAO-B

99.0 nM (IC₅₀)

体外研究
(In Vitro)

HDAC1/MAO-B-IN-1 (compound 1f) shows inhibitory activities with IC₅₀s of 99.0 nM, 9923.0 nM, 21.4 nM for hMAO-B, hMAO-A, hHDAC1, respectively^[1].
HDAC1/MAO-B-IN-1 (50 μM; 24 h) displays neuroprotective and inhibitory activity on ROS production in PC12 cells^[1].

Cell Viability Assay^[1]

Cell Line:	PC12 cells
Concentration:	50 μM
Incubation Time:	24 h
Result:	Displayed neuroprotective and inhibitory activity on ROS production.

体内研究
(In Vivo)

HDAC1/MAO-B-IN-1 (20 mg/kg; i.g.) exhibits favorable BBB (blood–brain barrier) permeability^[1].
HDAC1/MAO-B-IN-1 (15 mg/kg; i.p.) improves the learning and memory abilities of the ICR mice^[1].

Animal Model:	6-8 weeks, ICR male mice^[1]
Dosage:	20 mg/kg
Administration:	I.g.
Result:	Exhibited favorable BBB (blood–brain barrier) permeability.

Animal Model:	20-25 g, ICR female mice^[1]
Dosage:	15 mg/kg
Administration:	I.p.; 15 consecutive days
Result:	Improved the learning and memory abilities of the ICR mice.

分子量

328.79

Formula

C₁₈H₁₇ClN₂O₂

CAS 号

2759855-37-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.