HDAC6/8/BRPF1-IN-1

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HDAC6/8/BRPF1-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2484255-65-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

HDAC6/8/BRPF1-IN-1 是 HDAC6/8 和溴结构域 PHD 指状蛋白 1 (BRPF1) 的双重抑制剂。 HDAC6/8/BRPF1-IN-1 对 HDAC1、HDAC6 和 HDAC8 具有抑制活性，IC₅₀值分别为 797 nM、344 nM 和 908 nM。HDAC6/8/BRPF1-IN-1 对 BRPF1 具有抑制活性，K_d值为 175.2 nM。 HDAC6/8/BRPF1-IN-1 可用于癌症研究。

生物活性

HDAC6/8/BRPF1-IN-1 is a dual inhibitor of bothHDAC6/8 and the bromodomain and PHD finger containing protein 1 (BRPF1). HDAC6/8/BRPF1-IN-1 has inhibitory activity forHDAC1,HDAC6andHDAC8withIC₅₀values of 797 nM, 344 nM and 908 nM, respectively. HDAC6/8/BRPF1-IN-1 has inhibitory activity forBRPF1with anK_dvalue of 175.2 nM. HDAC6/8/BRPF1-IN-1 can be used for the research ofcancer^[1].

IC₅₀& Target^[1]

HDAC1

797 nM (IC₅₀)

HDAC6

344 nM (IC₅₀)

HDAC8

908 nM (IC₅₀)

体外研究
(In Vitro)

HDAC6/8/BRPF1-IN-1 has inhibitory activity for HDAC1, HDAC6 and HDAC8 with IC₅₀values of 797 nM, 344 nM and 908 nM, respectively^[1].
HDAC6/8/BRPF1-IN-1 has inhibitory activity for BRPF1 with an K_dvalue of 175.2 nM^[1].

分子量

387.41

Formula

C₁₈H₁₇N₃O₅S

CAS 号

2484255-65-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.