Chlamydocin, afungalmetabolite, is a highly potentHDACinhibitor, with anIC₅₀of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin inducesapoptosisby activating caspase-3^[1].

Chlamydocin is originally isolated from the fungusDiheterospora chlamydosporia. Chlamydocin exhibits a broad spectrum of antiproliferative activity toward various cancer cell lines, irrespective of their p53 status. The antiproliferative activity of Chlamydocin is accompanied by accumulation of hyperacetylated histones H3 and H4, induction of p21cip1/waf1, and accumulation of cells in G2/M phase of the cell cycle^[1].

526.62

C₂₈H₃₈N₄O₆

53342-16-8

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